ЛЕВОЛОРЕН eritma

Farmakodinamikasi

Levofloksasin DNK - girazani (topoizomeraza II) va topoizomeraza IV ni bloklaydi, DNK ning superspirilizasiyasi va uzilishlarning tikilishini buzadi, DNK sintezini ingibitsiya qiladi, tsitoplazma, xujayra devori va membranalarida chuqur morfologik o'zgarishlar chaqiradi.

Levofloksasin quyidagi mikroorganizmlarga nisbatan faol:

Aerob grammusbat mikroorganizmlar: Corynebacterium diphtheriae, Enterococcus faecalis, Enterococcus spp., Listeria monocytogenes, Staphylococcus coagulasenegative methi - S(I) [metisillinga-sezuvchan (metisillinga o'rtacha sezgirlar)], Staphylococcus aureus methi-S, Staphylococcus epidermidis-S, Stapylococcus spp (CNS), Staphylococcus spp (CNS), Streptococcus agallactiae, Streptococcus pneumoniae peni L/S/R (penisillinga sezgir - o'rtacha sezgir - rezistent), Streptococcus pyogenes, Viridans streptococci peni - S/R.

Aerob grammanfiy mikroorganizmlar: Acinetobacter baumannil, Acinetobacter spp., Actenobacillus actinomycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter aerogenes, Enterobacter agglomerates, Enterobacter cloacae, Enterobacter spp., Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae ampi-S/R (ampisillinga - sezgir - rezistept), Haemophilus parainfuenzae, Helicobacter pylori, Klebsiella oxytaca, Klebsiella pneumoniae, Klebsiella spp., Moraxelci catarrhal is (β+β-, Morganella morganii, Neisseria gonorrhoeae non PPNG/PPNG, Neisseria meningitides, Pasteurella conis, Pasreurella dagmatis, Pasteurella multocida, Pasteurella spp., Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Providencia spp., Pseudomonas aeruginosa, Pseudomonas spp., Salmonella spp., Serratia mctrcescens, Serratie spp.

Anaerob mikroorganizmlar: Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptoslreptococcus, Propionibacterum spp., Veilonellci spp.

Boshqa mikroorganizmlar: Bartonella spp., Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila, Legionella spp., Mycobacterium spp., Mycobacterium leprae, Micopbacterium tuberculosis, Mycoplasma hominis, Mycoplasma pneumoniae, Ricketsia spp., Ureaplasma urealyticum.

O'rtacha faol:

Aerob grammusbat mikroorgaiizmlar: Corynebasterium urealitium, Corynebacterium xerosis, Enterocoscus faecium, Staphylococcus epidermidis methi-R (metisillenga rezistentlar), Sfapylococcus haemolyticus methi-R.

aero6 grammanfiy mikroorganizmlar: Vurkholderia serasіa, Camrilobastsr jejuni/coli.

aNaepob mikroopganizmlap: Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides ovaius, Prevoitella spp., Porphyromonas spp,

Ppepapatga chidamli:

Aerob grammusbat mikroorganizmlar: Corynabacterium jeikeium, Staphylococcus aureus methi-R, Stophylococcus coagulase-negative methi-R.

Aerob grammanfiy mikroorganizmlar: Alsaligenes xylosaxidans

Boshqa mikroorganizmlar: Mycobacterium avium.

Farmakologik ta'sir

500 mg levofloksasin bir marta qabul qilinganidan keyingi farmakokinetik xarakteristikasi mos ravishda quyidagilarni tashkil qiladi: maksimal kontsentrasiya (Smax) 6,2±1,0 mkg/ml, maksimal kontsentrasiyaga erishish vaqti (Tmax) - 1,0±1,0 soat, yarim chiqariliish davri (T½) - 6,4±0,7 soat.

Levofloksasin asosan o'zgarmagan holda siydik bilan chiqariladi. Levofloksasinning o'rtacha yakuniy T½ bir martalik va ko'p martalik yuborishdan keyik 6 soatdan 8 soatgachani tashkil qiladi.

Buyrak etishmovchiligida preparatning klirensini kamayishi va uning buyraklar orqali chiqarilishi, kreatinin klirensiniig darajasini pasayishi bilan bog'liq.

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